Necas氏等偶然发现,S期特异性药物羟基脲可使小鼠血液中多能干细胞(CFUs)迅速消失。此作用令人惊异,因为处于静止期的CFUs细胞群对S期细胞杀伤药物相对不敏感。作者等使用几种细胞周期特异性药物(羟基脲、阿糖胞苷、甲氨蝶呤、秋水仙碱,长春碱和长春新碱)进行实验,观察它们对血液中CFUs的作用。实验采用雌性ICR小鼠,每组6只,在注射一次实 Occasionally, Necas et al. Found that the S phase-specific drug hydroxyurea rapidly disappeared in the blood of mice. This effect is surprising, as the quiescent CFUU population is relatively insensitive to S-phase cytotoxic agents. The authors used several cell-cycle-specific drugs (hydroxyurea, cytarabine, methotrexate, colchicine, vinblastine and vincristine) to test their effect on CFUs in the blood. Female ICR mice were used in the experiment, 6 in each group, and injected once