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观察腹水膏穴位贴敷对小鼠艾氏腹水癌的疗效 ,并从细胞因子角度探讨其治疗机理。采用艾氏腹水癌瘤株用NIH小鼠接种 ,随机分正常空白对照组 (正空组 )、模型对照组 (模对组 )、局部贴敷组 (局贴组 )、穴位贴敷组 (穴贴组 ) 4组进行观察研究。结果 ,与模对组相比 ,腹水膏局贴或穴贴均可显著延长荷瘤小鼠生存期 (P <0 0 5 ,P <0 0 1) ,显著抑制恶性腹水增长速度 (P <0 0 5 ,P <0 0 1) ,穴位贴敷优于局部贴敷 (P <0 0 5 ) ;腹水膏可下调外周血sIL 2R水平 (P <0 0 5 ) ,显著提高外周血TNF杀伤活性 (P <0 0 0 1)。艾氏腹水癌小鼠存在细胞因子网络的调节失衡 ,腹水膏治疗艾氏腹水癌疗效确切 ,其机理可能为下调外周血sIL 2R水平 ,提高外周血TNF杀伤活性 ,促进细胞免疫功能。
Observed the effect of ascites ointment application on Ehrlich ascites carcinoma in mice, and discussed its therapeutic mechanism from the perspective of cytokines. Ehrlich ascites carcinoma tumor strains were inoculated with NIH mice and randomly assigned to normal blank control group (positive empty group), model control group (model pair group), topical application group (local patch group), acupoint application group (hole Patch group) 4 groups were observed. Results Compared with the model group, ascites ointment topical or acupoint application significantly prolonged the survival time of tumor-bearing mice (P < 0.05, P <0.01), and significantly inhibited the growth rate of malignant ascites (P <0. 0 5, P <0 0 1), Acupoint application was better than local application (P <0 05); Ascites fluid could down-regulate the level of sIL 2R in peripheral blood (P <0 05), which significantly increased the activity of TNF in peripheral blood. (P < 0 0 0 1). There is an imbalance in the regulation of cytokine networks in Ehrlich’s ascites carcinoma mice. Ascites ointment is effective in the treatment of Ehrlich ascites carcinoma. The mechanism may be to downregulate the level of sIL 2R in the peripheral blood, increase the activity of TNF killing in peripheral blood, and promote cellular immunity.