自从把致癌性列入许多化学物质的毒性实验项目以来,金属的致癌性研究逐渐增多。对金属加工工业的长期流行病学调查也证明了金属的致癌性。表1是直到目前为止的金属致癌实验报告的总结。从表1可以看出,无论从实验研究还是从工业生产的流行病学调查来看,镍是致癌性很强的金属,特别是羰基镍,吸入时能引起鼻癌和肺癌。实验证明羰基镍抑制苯并芘羟化酶,或抑制该酶的诱导,使苯并芘的致癌性长期持续地起作用。目前只看到由吸入引起的癌症。已知铬可引起工人肺癌。铬酸盐的烟和雾最危险。经口投与是否致癌尚不明了。铍可致肺肉芽肿,虽然也有受检工人和附近 Since carcinogenicity has been included in many chemical toxicity programs, the carcinogenicity of metals has increased. Long-term epidemiological investigations of the metalworking industry have also demonstrated the carcinogenicity of metals. Table 1 is a summary of the metal carcinogenicity test report so far. As can be seen from Table 1, nickel is a highly carcinogenic metal, especially nickel carbonyl, which can cause both nasal and lung cancer when inhaled, both from experimental studies and from epidemiological surveys of industrial production. Experiments show that carbonyl nickel inhibition of benzopyrene hydroxylase, or inhibition of the induction of the enzyme, so that carcinogenicity of benzopyrene long-term continuous effect. Currently only see the cancer caused by inhalation. Chromium is known to cause lung cancer in workers. Chromate smoke and fog the most dangerous. It is unclear whether oral administration is carcinogenic. Beryllium can cause pulmonary granulomas, although there are also test workers and nearby