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目的:对盐酸丁咯地尔联合奥扎格雷钠治疗椎-基底动脉供血不足的临床疗效进行分析。方法:将63例诊断明确的椎-基底动脉供血不足患者随机分为2组,其中治疗组42例给予丁咯地尔200mg加入生理盐水500ml中静滴,1次/d;奥扎格雷钠80mg加入生理盐水100ml中静滴,2次/d,14天为1疗程。对照组20例给予血栓通注射液280mg加生理盐水250ml静滴,1次/d,14天为1疗程。2组同时辅以口服西比灵,合并有高血压、糖尿病、高脂血症、颈椎病等伴随疾病者分别给予相应治疗。结果:治疗组总有效率93.02%,对照组总有效率75.00%,治疗组疗效明显优于对照组,差异有显著性(P<0.05);TCD检测治疗组治疗前后VA、BA、PCA血流速度明显改变,与治疗前相比差异显著(P<0.05);与对照组比较治疗组治疗后VA、BA、PCA血流速度有明显改善,但无统计学意义(P>0.05)。结论:盐酸丁咯地尔联合奥扎格雷钠治疗椎-基底动脉供血不足效果显著,无明显不良反应,可在临床上推广应用。
Objective: To analyze the clinical efficacy of buflomedil hydrochloride combined with ozagrel sodium in the treatment of vertebrobasilar insufficiency. Methods: Sixty-three patients with vertebro-basilar insufficiency were randomly divided into 2 groups. 42 cases in the treatment group were treated with buflomedil 200 mg intravenously in 500 ml of normal saline once a day, 80 mg of ozagrel sodium Add 100ml of saline intravenously, 2 times / d, 14 days for a course of treatment. The control group of 20 cases given Xueshuantong injection 280mg normal saline 250ml intravenous infusion, 1 / d, 14 days for a course of treatment. Two groups were supplemented with oral xibinger, combined with hypertension, diabetes, hyperlipidemia, cervical spondylosis and other associated diseases were given the appropriate treatment. Results: The total effective rate was 93.02% in the treatment group and 75.00% in the control group. The curative effect in the treatment group was significantly better than that in the control group (P <0.05). The blood flow of VA, BA and PCA in the treatment group before and after treatment (P <0.05). Compared with the control group, the blood flow velocity of VA, BA and PCA in treatment group was significantly improved, but there was no statistical significance (P> 0.05). CONCLUSION: Buflomedil hydrochloride plus ozagrel sodium is effective in treating vertebrobasilar insufficiency. It has no obvious adverse reactions and can be widely applied in clinic.