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阿弗他溃疡是一种常见疾病,发作频繁,影响患者的正常生活,目前尚无安全有效的治疗方法。作者用5%5-氨基水物杨酸(5-ASA)霜和安慰剂随机双盲对照试验治疗22例反复发作自愿参加试验的阿弗他溃疡患者。治疗及对照组各11例,两组在年龄、性别和溃疡数目等无明显区别。每日饭后于患处涂擦药物共3次,直到溃疡愈合或至14天为止。在治疗前和治疗后7,14和28天,通过观察溃疡的数目、病程、不适程度、痛觉和进食困难等几个方面来评价疗效。结果,治疗组和对照组口腔不适感减轻平均天数分别是7天和17天(P<0.01),治疗组在治疗7天时较对照组痛觉有84%减
Aphthous ulcer is a common disease, frequent seizures, affecting the normal life of patients, there is no safe and effective treatment. The authors treated 22 patients with aflatoxins who had repeated episodes of voluntary participation in the trial with 5% 5-aminosalicylic acid (5-ASA) cream and placebo in a randomized double-blind controlled trial. Treatment and control group of 11 cases, two groups in age, gender and the number of ulcers no significant difference. Rub the medicine three times daily in the affected area until the ulcer has healed or until 14 days. Before treatment and 7,14 and 28 days after treatment, by observing the number of ulcers, duration, degree of discomfort, pain and eating difficulties in several aspects to evaluate the efficacy. Results The average number of days to relieve oral discomfort in the treatment group and control group was 7 days and 17 days, respectively (P <0.01), and the treatment group had a pain relief of 84% less than the control group on the 7th day of treatment