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钩端螺旋体病（下称钩体病）经用青霉素G治疗可取得满意疗效，但给药后4～6小时内能发生赫氏反应，后者提示药物发挥了抗钩体的作用，但同时却对病人产生了不良后果。个别病例在赫氏反应后可以迅速演变为肺弥漫性出血而死亡。近年来我省钩体病病死率增高的主要原因之一就是由于青霉素G治疗后，赫氏反应的发生率有增高的趋势，甚至高达40～80％。
Leptospirosis (hereinafter referred to leptospirosis) with penicillin G treatment can be obtained with satisfactory results, but within 4 to 6 hours after administration can occur Heath’s reaction, the latter prompted the drug to play a role in anti-hook body, but at the same time But the patient had adverse consequences. In some cases, Heath’s reaction can rapidly evolve into diffuse hemorrhage and death of the lungs. In recent years, one of the main reasons for the increased mortality of leptospirosis in our province is that the incidence of Herz ’s reaction tends to increase after treatment with penicillin G, even up to 40-80%.