目的系统评价利用血清胱抑素C与尿微量白蛋白监测2型糖尿病早期肾损害的作用,探讨临床监测2型糖尿病肾功能的最佳手段。方法通过数据库检索国内相关文献,选择评价纳入研究的方法学和提取有效数据后,按Corhrane协作网提供的Meta分析对其进行定量综合分析。结果共有15篇文献纳入标准,2型糖尿病早期血清胱抑素C异常检出率高于尿微量白蛋白,合并OR值为1.95,95%CI为(1.39,2.75)。结论血清胱抑素C是评价2型糖尿病肾功能的灵敏指标,且稳定性好,有利于肾功能损害的早期筛查。 Objective To evaluate the role of serum cystatin C and urinary microalbuminuria in the detection of early renal damage in type 2 diabetic patients and to explore the best way to monitor the renal function of type 2 diabetic patients clinically. METHODS: After searching the domestic literature through database, choosing the methodologies of the included studies and extracting the valid data, we conducted a quantitative and comprehensive analysis according to the Meta analysis provided by the Corhrane Collaboration. Results A total of 15 articles were included in the standard. The detection rate of early abnormal serum cystatin C in type 2 diabetes patients was higher than that of urinary microalbuminuria (OR = 1.95, 95% CI 1.39, 2.75). Conclusion Serum cystatin C is a sensitive indicator of renal function in type 2 diabetic patients and its stability is good, which is good for early screening of renal dysfunction.