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细胞外基质（ＥＣＭ）在肾小球硬化中的作用已成为热门话题，作为ＥＣＮ的主要成分－Ⅳ型胶原也受到广泛重视。目前发现Ⅳ型胶原在肾小球硬化时合成及分泌明显增加；在Ａｌｐｏｒｔ综合征及Ｇｏｏｄｐａｓｔｕｒｅ综合征存在Ⅳ型胶原链基因突变或结构异常，本文就Ⅳ型胶原分子结构、编码基因、在肾组织中的分布以及Ⅳ型胶原在肾脏疾病中的改变加以综述。
The role of extracellular matrix (ECM) in glomerulosclerosis has become a hot topic. As a major component of ECN, type IV collagen has also been widely recognized. It has been found that type Ⅳ collagen in glomerular sclerosis synthesis and secretion increased significantly; in Alport syndrome and Goodpasture syndrome type Ⅳ collagen chain gene mutations or structural abnormalities, collagen type Ⅳ collagen gene structure, encoding genes in renal tissue In the distribution and type Ⅳ collagen in renal disease changes are reviewed.