论文部分内容阅读
一般认为,在慢性HBV感染期间,受染肝细胞的崩解系由宿主免疫反应介入所致,涉及的主要效应细胞是CD_8~+细胞毒性T淋巴细胞,但这些淋巴细胞功能上受HLAI类抗原的限制。已知干扰素免疫调节作用之一是诱导包括外周血单核细胞(PBMC)和肝细胞在内的细胞膜表面的HLAI类抗原密度增高。据认为,干扰素通过这一机制在慢性乙型肝炎中产生反应。为了进一步弄清治疗反应与诱导的HLAI
It is generally believed that during the chronic HBV infection, the disintegration of the infected hepatocytes is caused by the host immune response, and the major effector cells involved are CD8 + cytotoxic T lymphocytes, but these lymphocytes are functionally affected by the HLA class I antigens limits. It is known that one of the effects of interferon immunomodulation is to induce an increase in the density of HLAI-like antigens on the surface of cell membranes, including peripheral blood mononuclear cells (PBMCs) and hepatocytes. It is thought that interferon responds to chronic hepatitis B through this mechanism. To further understand the therapeutic response and induction of HLAI