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过敏性休克是由过敏性物质(通常大都是药物及血清)进入过敏体质的机体,成为机体的抗原(药物如青霉素等大都是半抗原,在血液中与血浆蛋白结合成全抗原)刺激网状内皮系统产生相应的抗体(IgE),该抗体是一种亲细胞抗体,其 Fc(可结晶片段)端能持久地结合在嗜碱粒细胞及毛细血管周围的肥大细胞表面,使机体处于致敏状态。当第二次同一抗原进入机体,即与结合在嗜碱粒细胞及肥大细胞表面的 IgE抗体的 Fab(抗原结合片段)端结合,一个抗原可结合多个抗体,使靶细胞表面的 IgE 分子联结如“搭桥”,
Anaphylactic shock is an allergic substance (usually mostly drugs and serum) into the body of the allergic body, as the body’s antigens (drugs such as penicillin are mostly haptens, in the blood and plasma protein binding to the whole antigen) to stimulate the reticuloendothelial The system produces a corresponding antibody (IgE), which is a pro-cell antibody whose Fc (crystallizable fragments) end binds permanently to the surface of mast cells around basophils and capillaries, allowing the body to be sensitized . When the second identical antigen enters the body, that is, binds to the Fab (antigen-binding fragment) end of an IgE antibody that binds to the surface of basophils and mast cells, one antigen binds to multiple antibodies and binds IgE molecules on the surface of the target cell Such as “bypass”