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宣痹安痛方为临床治疗冠心病的经验方,该研究确定其最佳水提醇沉工艺参数。采用L9(34)正交设计法对宣痹安痛方进行提取醇沉工艺的研究,以出膏率、丹酚酸B、黄连总生物碱、芍药苷、葛根素、皂苷Rb1、松果菊苷等指标成分含量为考察指标,采用多指标综合加权评分的方法优选出最佳提取醇沉工艺,并对该优选工艺进行验证。结果显示,最佳提取工艺参数为10倍加水量、煎煮时间0.5 h、煎煮3次;最佳醇沉工艺为浓缩液1.12(20℃测),加入乙醇使含醇量达到70%,放置24h。优化后的水提醇沉工艺稳定可靠,可为进一步开发利用该处方提供参考。
Xuanbi Anya for the clinical treatment of coronary heart disease side experience, the study to determine the best water extraction alcohol deposition process parameters. The orthogonal design method of L9 (34) was used to study the alcohol precipitation process of Xuanbi An Tongfang. The effects of the extraction rate, Sal B, Coptidis alkaloids, paeoniflorin, puerarin, saponin Rb1, Glycosides and other indicators of the content of indicators for the inspection indicators, the use of multi-index comprehensive weighted score method to optimize the optimal extraction alcohol precipitation process, and verify the preferred process. The results showed that the optimal extraction process parameters were 10 times the amount of water, boiling time 0.5 h, boiling 3 times; the best alcohol precipitation process for the concentrate 1.12 (20 ℃ measured), adding ethanol to 70% alcohol content, place 24h. Optimized water extraction and alcohol precipitation process is stable and reliable, which can provide reference for further development and utilization of the prescription.