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目的:探讨索他洛尔对重症心肌炎合并恶性心律失常(MVA)的影响。方法:将59例患者分为索他洛尔组39例及对照组20例,分别监测血压、心率、心电图、QTc、24 h动态心电图,观察各阶段MVA发生率。结果:索他洛尔对室性心律失常的总有效率87.2%,用药过程中仅有心率减慢、QTc延长及早期收缩力下降。结论:索他洛尔能有效降低重症心肌炎合并MVA的发生率。
Objective: To investigate the effect of sotalol on severe myocarditis complicated with malignant arrhythmia (MVA). Methods: 59 patients were divided into sotalol group (n = 39) and control group (n = 20). Blood pressure, heart rate, electrocardiogram, QTc and 24 h electrocardiogram were monitored. The incidence of MVA in each stage was observed. Results: The total effective rate of sotalol to ventricular arrhythmia was 87.2%. Only heart rate, QTc prolongation and early contractility decreased during the course of medication. Conclusion: Sotalol can effectively reduce the incidence of severe myocarditis associated with MVA.