天疱疮系一种较罕见的皮肤病,目前多认为属自体免疫性疾病。迄今尚未见到有关这种病的电镜观察材料。本文介绍对天疱疮损害处皮肤的电镜观察结果。病历摘要:患者男性,38岁。临床皮检及病理组织学均诊断为寻常性天疱疮。血清检查IgG45.30mg/ml,IgA3.32mg/ml,IgM1mg/ml。一、表皮棘层超微病变的电镜观察在表皮之基底层上方发生棘层松解,未见炎细胞浸润。在早期损害处不但相邻棘细胞之间(非桥粒区)的间隙开始增宽,而且桥粒区棘细胞之间的间隙也明显增宽,宽达50nm(正常为20nm),间隙中粘合物质的密度减低、 Pemphigus is a relatively rare skin disease, currently considered an autoimmune disease. To date, no electron microscopy material has been found for this condition. This article presents the electron microscopic observation of skin lesions at pemphigus. Medical record summary: Male patient, 38 years old. Clinical examination and histopathology were diagnosed as pemphigus vulgaris. Serum test IgG45.30mg / ml, IgA3.32mg / ml, IgM1mg / ml. First, epidermal spine superficial lesions electron microscopy in the epidermis above the basal layer occurred acantholysis, no inflammatory cell infiltration. Not only in the early damage between adjacent spine cells (non-desmosome region) began to broaden the gap, and bridge the dendritic cell gap was also significantly widened, up to 50nm (normal 20nm), the gap sticky Combined material density is reduced,