TNF受体相关因子(TNF receptor-associated factor,TRAF)是连接免疫受体(包括TNF受体和Toll样受体)和下游信号转导至关重要的接头蛋白,其活化失调有可能导致过度炎症,引起组织损伤。Bill研究小组发现,FBXL2(F-box and leucine-rich re-peat protein 2)和FBXO3(F-box only protein 3)能够通过影响TRAF的稳定性来调控机体炎症反应,其论文发表在Nat Immunol Tumor necrosis factor receptor-associated factor (TRAF) is a crucial adapter protein that binds to immune receptors (including TNF receptors and Toll-like receptors) and downstream signaling and its dysregulation may lead to over-inflammation , Causing tissue damage. Bill’s team found that FBXL2 (F-box and leucine-rich re-peat protein 2) and FBXO3 (F-box only protein 3) can regulate the body’s inflammatory response by affecting the stability of TRAF. The paper was published in Nat Immunol