论文部分内容阅读
目的:探讨Ezrin在涎腺腺样囊性癌组织中的表达及意义。方法:用免疫组织化学SP法检测Ezrin在涎腺腺样囊性癌组织和正常涎腺组织中的表达,分析其在涎腺腺样囊性癌组织中的表达与肿瘤的侵袭性、复发、转移和预后的关系。结果:Ezrin在涎腺腺样囊性癌和正常涎腺组织中的阳性率表达分别为44.68%和9.09%,P<0.05;在癌细胞中主要为胞质内表达,染色深,而在正常涎腺组织则主要为细胞膜表达,染色浅或阴性。Ezrin的表达强度与有无神经受侵、有无发生局部复发及远处转移相关,P<0.05。Ezrin表达阳性组和阴性组的5年累积生存率分别为66.70%和100.00%,10年累及生存率分别为27.83%和95.00%,阳性组较阴性组预后差,P<0.05。结论:Ezrin的表达强度与涎腺腺样囊性癌的发生、侵袭性、复发和转移性有关,且Ezrin阳性表达预示患者预后不良。
Objective: To investigate the expression of Ezrin in salivary adenoid cystic carcinoma and its significance. Methods: The expression of Ezrin in salivary adenoid cystic carcinoma and normal salivary gland tissues was detected by immunohistochemical SP method. The expression of Ezrin in salivary adenoid cystic carcinoma was analyzed with the invasiveness, recurrence, Relationship between metastasis and prognosis. Results: The positive expression rates of Ezrin in salivary adenoid cystic carcinoma and normal salivary gland tissues were 44.68% and 9.09%, respectively, P <0.05. The expression of Ezrin in cytoplasm was mainly in cytoplasm, Salivary gland tissue is mainly cell membrane expression, staining light or negative. Ezrin expression intensity with or without nerve invasion, with or without local recurrence and distant metastasis, P <0.05. The 5-year cumulative survival rates of Ezrin-positive and -negative groups were 66.70% and 100.00%, respectively. The 10-year cumulative survival rates were 27.83% and 95.00% respectively. The positive rates of Ezrin in the positive and negative groups were lower than those in the negative group (P <0.05). Conclusion: The expression of Ezrin is related to the occurrence, invasion, recurrence and metastasis of salivary adenoid cystic carcinoma. The positive expression of Ezrin indicates the poor prognosis of patients.