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近年来,长期应用β_2—肾上腺素能受体(β_2受体)激动剂的潜在危险已渐渐被认识。临床医师有必要了解β_2受体的分子结构、β_2受体激动剂(配体)如何与受体结合产生细胞内的生化效应、以及受体的减敏机制,从而认识其潜在危险的本质问题,更加合理地使用β_2受体激动剂。 β_2受体是鸟嘌呤三磷酸核苷结合蛋白(G蛋白)的偶联受体之一,是最佳的跨膜信息研究模型。信息跨膜传递的过程是:外界信息分子
In recent years, the potential dangers of long-term use of β 2 -adrenoceptor (β 2 receptor) agonists have been increasingly recognized. It is necessary for clinicians to understand the molecular structure of β 2 receptor, how the β 2 receptor agonist (ligand) binds to the receptor to produce intracellular biochemical effects, and the desensitization mechanism of the receptor to recognize the underlying problem of its potential danger. Use beta 2 receptor agonists more reasonably. The β 2 receptor is one of the coupled receptors of guanine nucleotide nucleoside binding protein (G protein) and is the best model of transmembrane information research. Transmembrane transmission of information is the process: external information molecules