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目的探讨丹栀逍遥胶囊联合醋酸亮丙瑞林治疗儿童中枢性性早熟(CPP)的临床疗效。方法选取2015年3月至2016年12月在信阳市中心医院就诊的CPP女性患儿106例,采用随机数字表法将其分为对照组和观察组,每组53例。对照组患儿皮下注射醋酸亮丙瑞林,观察组患儿在对照组治疗基础上加用丹栀逍遥胶囊。比较2组患儿治疗后卵巢体积、子宫体积、骨龄指数、性激素水平、身高增速的变化以及临床疗效和不良反应。结果治疗前2组患儿卵巢体积、子宫体积、骨龄指数比较差异均无统计学意义(P>0.05);治疗后,2组患儿卵巢体积、子宫体积、骨龄指数均显著低于治疗前(P<0.05),且观察组患儿卵巢体积、子宫体积、骨龄指数均显著低于对照组(P<0.05)。治疗前2组患儿血清中黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E_2)水平比较差异无统计学意义(P>0.05);治疗后,2组患儿血清中LH、FSH、E2水平均较治疗前显著降低(P<0.05),且观察组患儿血清中LH、FSH、E_2水平均显著低于对照组(P<0.05)。观察组患儿身高增速为(4.52±0.83)cm·a~(-1),显著低于对照组患儿的(7.35±1.02)cm·a~(-1)(P<0.05)。观察组患儿治疗总有效率为92.45%,显著高于对照组患儿的73.58%(χ~2=6.692,P<0.05)。治疗期间2组患儿均未出现不良反应。结论丹栀逍遥胶囊联合醋酸亮丙瑞林治疗儿童CPP疗效显著,不良反应少,可有效调节机体性激素,延迟发育时间。
Objective To investigate the clinical efficacy of Danzhi Xiaoyao Capsule combined with leuprolide in the treatment of children with central precocious puberty (CPP). Methods From March 2015 to December 2016, 106 women with CPP who were treated in Xinyang Central Hospital were randomly divided into control group and observation group with 53 cases in each group. Children in the control group were subcutaneously injected with leuprolide acetate. The children in the observation group received Dan Zhi Xiaoyao Capsule on the basis of the control group. The volume of ovary, the volume of uterus, the index of bone age, the level of sex hormones, the growth of height and the clinical efficacy and adverse reactions of the two groups were compared. Results There was no significant difference in ovarian volume, uterine volume and bone age index between the two groups before treatment (P> 0.05). After treatment, the volume of ovary, the volume of uterus and the index of bone age in both groups were significantly lower than those before treatment P <0.05). The ovarian volume, uterine volume and bone age index in the observation group were significantly lower than those in the control group (P <0.05). The levels of serum LH, FSH and E2 in the two groups before treatment were not significantly different (P> 0.05). After treatment, the levels of serum LH The levels of LH, FSH and E2 in the observation group were significantly lower than those in the control group (P <0.05). The levels of LH, FSH and E2 in the observation group were significantly lower than those in the control group (P <0.05). The height growth of the observation group was (4.52 ± 0.83) cm · a -1, which was significantly lower than that of the control group (7.35 ± 1.02 cm · a -1) (P <0.05). The total effective rate of observation group was 92.45%, significantly higher than that of control group (73.58%) (χ ~ 2 = 6.692, P <0.05). No adverse reactions occurred in both groups during treatment. Conclusion Danzhi Xiaoyao Capsule combined with leuprolide acetate in the treatment of children with significant effect of CPP, adverse reactions, can effectively regulate body sex hormones, delayed development time.