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对８５例早期流产患者采用酶联免疫吸附法测定外周血肿瘤坏死因子（ＴＮＦ－α）、可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）以及采用流式细胞仪检测外周血Ｔ淋巴细胞亚群（总Ｔ淋巴细胞，ＣＤ３；Ｔ辅助，ＣＤ４；Ｔ抑制，ＣＤ８）。流产患者分为三组：２５例难免或不全流产（ＥＡ），先兆流产２０例治疗失败（ＴＡＦ）及３８例治疗成功（ＴＡＳ）。选择正常早孕妇女（ＮＰ）及非孕妇女（ＮＮＰ）各２０例为对照。结果：①血清ＴＮＦ－α、ｓＩＬ－２Ｒ水平在ＥＡ、ＴＡＦ、ＴＡＳ组分别明显高于ＮＰ组（Ｐ＜０．０５），且在ＥＡ、ＴＡＦ组较ＴＡＳ组明显升高（Ｐ＜０．０５）。血清ＴＮＦ－α、ｓＩＬ－２Ｒ水平在ＮＰ组与ＮＮＰ组没有明显差异（Ｐ＞０．０５）。②ＣＤ８细胞在ＥＡ、ＴＡＦ组分别明显低于ＴＡＳ、ＮＰ组（Ｐ＜０．０５），ＣＤ３、ＣＤ４在各组没有明显差异（Ｐ＞０．０５）。提示：自然流产可能与机体免疫异常有关。
Serum levels of tumor necrosis factor (TNF-α), soluble interleukin-2 receptor (sIL-2R) and the level of T lymphocyte subsets in peripheral blood were measured by enzyme-linked immunosorbent assay in 85 cases of early abortion. Population (total T lymphocytes, CD3; T helper, CD4; T inhibition, CD8). Abortion patients were divided into three groups: 25 cases of inevitable or incomplete abortion (EA), 20 cases of threatened abortion (TAF) and 38 cases of successful treatment (TAS). 20 normal pregnant women (NP) and non-pregnant women (NNP) were selected as control. Results: ① The serum levels of TNF-α and sIL-2R in EA, TAF and TAS groups were significantly higher than those in NP group (P <0.05), and significantly higher in EA and TAF groups than those in TAS group (P <0. 05). Serum levels of TNF-α and sIL-2R were not significantly different between NP group and NNP group (P> 0.05). ②CD8 cells in EA, TAF group were significantly lower than TAS, NP group (P <0.05), CD3, CD4 in each group had no significant difference (P> 0.05). Tip: spontaneous abortion may be related to the body’s immune abnormalities.