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目的:探讨血管紧张素转换酶2(angiotensin-converting enzyme2,ACE2)基因rs2106809多态性与服用苯那普利后血压变化情况的关联,以及rs2106809与血管紧张素Ⅱ的1型受体(angiotensinⅡtype1receptor,AGTR1)和血管紧张素原(angiotensinogen,AGT)基因位点之间的交互作用。方法:在1831名高血压患者服用苯那普利2周的基础上,分析rs2106809与血压变化指标的关联,使用广义多因子降维法(generalized multifactor dimensionality reduc-tion,GMDR)分析rs2106809与AGTR1基因8个位点和AGT基因3个位点的交互作用。结果:rs2106809与女性服药后收缩压和脉压差变化情况相关,与男性脉压差变化情况相关,携带T等位基因者降压幅度较大。在男性收缩压变化情况的分析中发现了多基因参与的交互作用模型。结论:rs2106809可能以独立危险因素或交互作用组分的形式影响苯那普利的降压水平。
Objective: To investigate the relationship between rs2106809 polymorphism of angiotensin-converting enzyme 2 (ACE2) gene and blood pressure changes after benazepril treatment, and the relationship between rs2106809 and angiotensin Ⅱ type 1 receptor AGTR1) and angiotensinogen (AGT) gene loci. Methods: Based on two weeks of benazepril treatment in 1831 hypertensive patients, the association between rs2106809 and blood pressure was analyzed. The rs2106809 and AGTR1 genes were analyzed by generalized multifactor dimensionality reduction (GMDR) 8 loci and AGT gene 3 loci interaction. Results: rs2106809 was associated with changes of systolic blood pressure and pulse pressure in women after taking medicine, and was related to changes of pulse pressure difference in males. In the analysis of male changes in systolic pressure, a multi-gene interaction model was found. CONCLUSIONS: rs2106809 may affect benazapril in the form of independent risk factors or interacting components.