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应用血清学、病理学、DNA 组化、免疫组化及 DNA 形态计量等方法研究 HCMV 致畸机理。结果表明母亲 HCMV 可通过胎盘经血传给胎儿。胎儿感染 HCMV 后,HCMV 随血流侵犯各脏器,在血管周围形成多灶性病变,单个细胞呈破坏性损害。病毒大量复制后细胞溃破,病毒再次进入血液,又传递至各脏器,故各脏器呈分批感染,病变呈现时间差。致病损、致畸程度取决于器官单个细胞受损部位、性质、数量及该器官所处的发育成熟期。
Serological, pathological, DNA histochemistry, immunohistochemistry and DNA morphology measurement methods of HCMV teratogenicity. The results showed that mothers HCMV can be transmitted through the placenta to the fetus. HCMV fetuses infected with blood flow, HCMV invasion of various organs with blood flow, the formation of multi-focal lesions in the blood vessels, single cells were destructive damage. After a large number of virus replication of cells ulceration, the virus re-enter the blood, but also transmitted to the organs, so the organ was infected in batches, lesions showed poor time. Pathological lesions, teratogenicity depends on the damaged parts of an organ, nature, quantity and developmental maturity of the organ.