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本文采用间接免疫荧光技术研究了汉防己甲素(简称汉甲素)治疗及停药后矽肺大鼠肺中蛋白多糖(PG)的变化。在发生矽肺纤维化时,肺泡间隔中PG含量明显增高。矽结节内PG发绿色荧光并呈云雾状分布于胶原纤维束表面及胶原纤维束之间。说明PG参与了矽肺纤维化,也是砂结节的组分之一。汉甲素治疗后,胶原和PG松解断裂,成为片断。肺泡和矽结节内有大量细胞浸润,其胞浆内含发射绿色荧光的PG。细胞对PG的吞噬加速了PG的分解代谢,进而影响了胶原纤维的聚合。
In this paper, indirect immunofluorescence was used to study the changes of proteoglycans (PG) in the lungs of silicotic rats after treatment with tetrandrine (abbreviation). In the occurrence of pulmonary fibrosis, the PG content in the alveolar septum was significantly increased. The PG in the sacral nodule developed green fluorescence and clouded on the surface of the collagen fiber bundle and between the collagen fiber bundles. This shows that PG is involved in the fibrosis of the lung, and it is also one of the components of the sand nodules. After treatment with iranisac, collagen and PG break loose and become fragments. There are a large number of cell infiltrate in the alveolar and popliteal nodules, and their cytoplasm contains green fluorescent PG. The phagocytosis of PG by cells accelerates the catabolism of PG, which in turn affects the polymerization of collagen fibers.