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目的探讨血胱氨酸蛋白酶抑制剂C(Cys-C)在高血压、糖尿病中早期肾损害的的诊断价值。方法胶乳增加免疫比浊法测定53例高血压患者、48例糖尿病患者、4例肾移植的Cys-C;采用酶法测定血清肌酐(SCr),并进行相关分析。结果高血压、糖尿病的Cys-C水平高于正常对照组,其异常检出率高于血清尿素氮、肌酐。结论Cys-C是反映早期肾功能损害的一项敏感而可靠的指标。
Objective To investigate the diagnostic value of cystatin C (Cys-C) in the early stage of renal damage in hypertension and diabetes mellitus. Methods Immunocytochemistry was used to determine the serum level of Cys-C in 53 hypertensive patients, 48 diabetic patients and 4 renal transplant recipients. Serum creatinine (SCr) was measured by enzyme-linked immunosorbent assay (ELISA). Results The levels of Cys-C in hypertension and diabetes mellitus were higher than those in normal control group, and the abnormal detection rate was higher than that of serum urea nitrogen and creatinine. Conclusion Cys-C is a sensitive and reliable indicator of early renal impairment.