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目的:观察宫颈癌患者腹腔镜术后应用动脉介入化疗的疗效及毒副反应。方法:160例宫颈癌患者,按随机数字表法分为治疗组和对照组,各80例。两组患者均行腹腔镜辅助阴式子宫广泛切除术,术后对照组患者采用紫杉醇+卡铂(TC方案)传统静脉化疗;治疗组患者采用TC方案动脉介入化疗。观察两组患者治疗后有效率、生存时间、生存率及毒副反应。结果:治疗后,治疗组患者有效率(90.0%)显著高于对照组(75.0%),差异均有统计学意义(P<0.05);治疗组与对照组患者平均生存时间分别为(23.45±5.33)、(19.29±6.13)月,生存率分别为91.3%、78.8%,差异有统计学意义(P<0.05);两组患者在治疗期间均出现不同程度的骨髓抑制及恶心呕吐等胃肠道反应,治疗组患者毒副反应发生的例数与严重程度均明显低于对照组,差异有统计学意义(P<0.05)。结论:动脉介入化疗能提高宫颈癌患者腹腔镜术后化疗效果,且毒副反应少,患者生存率提高。
Objective: To observe the curative effect and side effects of arterial chemotherapy after laparoscopic surgery for patients with cervical cancer. Methods: 160 cases of cervical cancer patients were divided into treatment group and control group according to random number table method, 80 cases each. Laparoscopy assisted vaginal hysterectomy was performed in both groups. The patients in the control group received conventional intravenous chemotherapy with paclitaxel + carboplatin (TC regimen) after surgery. The patients in the treatment group received arterial chemotherapy with TC regimen. Observed two groups of patients after treatment efficiency, survival time, survival rate and toxicity. Results: After treatment, the effective rate (90.0%) in treatment group was significantly higher than that in control group (75.0%), the difference was statistically significant (P <0.05); the average survival time in treatment group and control group were (23.45 ± 5.33) and (19.29 ± 6.13) months, the survival rates were 91.3% and 78.8%, respectively, with significant difference (P <0.05). Both groups had different degrees of myelosuppression and nausea and vomiting during the treatment Road reaction, the treatment group patients with side effects and severity of cases were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion: Arterial intervention chemotherapy can improve the efficacy of laparoscopic chemotherapy in cervical cancer patients with less side effects and higher survival rate.