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作者对中国西双版纳傣族、上海地区汉族德国白人和土耳其白人四个群体进行了HLA-A~*02多位基因分析。应用2对引物和24个地高辛标记的探针可检出17个等位基因。结果表明两个中国群体A2等位基因分布与白人有明显差异,A~*0201是德国（90％）和土耳其（80％）人的主要等位基因,在汉族和傣族中则分别为40％与2.2％。同为中国人的傣族和汉族A02等位基因分布也显著不同,A~*0207是傣族的最常见等位基因。结果尚表明中国群体中A~*0207与B46强相关,傣族尤为明显,连锁不平衡多数达9.15。在傣族中与A~*02关联的单倍型以 A~*0207-B46-DR9为最常见。HLA-A~*02等位基因分布在不同群体、不同民族、不同地区的差异将对基础免疫研究及器官移植配型有重大意义。
The authors performed HLA-A * * 02 multi-locus analysis of four populations of white Han nationality and white Turkish Han nationality in Dai nationality of Xishuangbanna in China and Han nationality in Shanghai. Seven pairs of primers and 24 digoxigenin-labeled probes detected 17 alleles. The results showed that A2 allele distribution in two Chinese populations was significantly different from that in whites. A ~ * 0201 was the major allele in Germany (90%) and Turkey (80%), with 40% With 2.2%. The distribution of A02 alleles in Dai and Han Chinese, both Chinese and Chinese, was also significantly different. A ~ * 0207 was the most common allele in Dai. The results also show that Chinese population A ~ * 0207 strongly correlated with B46, Dai is particularly evident, the majority of linkage disequilibrium reached 9.15. The haplotypes associated with A ~ * 02 in Dai were the most common with A ~ * 0207-B46-DR9. The distribution of HLA-A * 02 alleles in different groups, ethnic groups and different regions will be of great significance to the study of basic immunology and the matching of organ transplantation.