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214例结核病患者分两组治疗,第一组173例采用利福平(每天600毫克)加异菸肼加链霉素或乙胺丁醇。173例中60例在治疗前即有不同程度的肝功能损害,包括22例肝穿刺活检证实有肝硬化或脂肪肝。第二组41例不用利福平,其它抗结核药物治疗同前组。对照组124例为接受激素、抗菌素或抗癌治疗的非结核病病人。结果 1.血清转氨酶:用利福平的173例中40例(23％)于治疗后10～90天发生血清转氨酶升高,而不用利福平的结核治疗组41例中仅发生3例(7.5％)。对照组124例中有5例(4％)治疗后转氨酶升高。2.黄疽:共发现17例黄疸,其中16例属第一组,1例属第二组;17例黄疸中有12例作了HBAg测定,其中7例阳性,5例阴性。HBAg阳性的7例其血清转
Two hundred and twenty-four patients with tuberculosis were divided into two groups. The first group of 173 patients received rifampin (600 mg daily) plus isoniazid plus streptomycin or ethambutol. Sixty-three of 173 patients had different degrees of liver damage before treatment, including 22 liver biopsy confirmed cirrhosis or fatty liver. The second group of 41 patients without rifampicin, other anti-TB drug treatment with the former group. In the control group, 124 patients were non-TB patients receiving hormone, antibiotic or anti-cancer therapy. Serum transaminases: Serum aminotransferases were elevated in 40 (23%) of the 173 patients treated with rifampicin 10 to 90 days after treatment, compared with only 3 (41) of the patients without rifampicin 7.5%). In the control group, 5 (4%) of 124 patients had elevated aminotransferases. Jaundice: A total of 17 cases of jaundice were found, of which 16 were in the first group and one in the second group. Of the 17 jaundice cases, 12 were tested for HBAg, of which 7 were positive and 5 were negative. 7 cases of HBAg positive seroconversion