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山莨菪碱(654—2)给小鼠静注11.2,12.3,15.4,20.5和30.0mg/kg表现出抗心律失常作用,其作用强度随剂量增大而增强。能够减少CaCl_2—Ach引起的小鼠房颤(扑)的发生率;增加BaCl_2所致室性心动过速转复窦性节律的大鼠数;加大诱发小鼠室性心律失常所需乌头碱的用量。654—2 20·5mg/kg也可降低CaCl_2(120mg/kg静注)引起的大鼠室颤以及氯仿—肾上腺素所致家兔室性心律失常的发生率。
Anisodamine (654-2) administered to mice at doses of 11.2, 12.3, 15.4, 20.5, and 30.0 mg / kg showed anti-arrhythmic effects with increased intensity with increasing doses. Can reduce the incidence of atrial fibrillation (flutter) induced by CaCl 2 -Ach in mice; increase the number of rats that recapitulate sinus rhythm caused by BaCl 2 -induced ventricular arrhythmia; increase the number of aconites The amount of alkali. 654-2 20 · 5mg / kg can also reduce the incidence of ventricular fibrillation induced by CaCl_2 (120mg / kg intravenous injection) and the incidence of ventricular arrhythmia induced by chloroform-adrenaline in rabbits.