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背景:有关核因子(NF)-κB和环氧合酶(COX)-2在肿瘤组织中表达的研究虽然较多,但其临床意义和相互关系尚无定论。目的:研究NF-κB和COX-2在胃癌组织中的表达及其关系。方法:采用免疫组化SP法检测142例胃癌组织中NF-κB和COX-2蛋白的表达,以相应的癌旁正常组织(30例)作对照。结果:NF-κB在胃癌组织中的阳性表达率为62.0%,显著高于对照组(P<0.01);NF-κB的表达与组织学类型、淋巴结转移和远处转移的临床指标呈显著相关(P<0.05)。COX-2在胃癌组织中的阳性率为64.1%,在对照组中无表达,两者比较有显著性差异(P<0.01),且在淋巴结转移组阳性率显著高于无转移组(P<0.01)。胃癌组织中NF-κB和COX-2的表达呈显著正相关(r=0.380,P<0.01)。结论:NF-κB和COX-2在胃癌的发生、发展中起重要作用,NF-κB可能促进了COX-2的表达。
BACKGROUND: Although there are many studies on the expression of nuclear factor (NF) -κB and cyclooxygenase (COX) -2 in tumor tissues, the clinical significance and the relationship between them are not conclusive. Objective: To study the expression of NF-κB and COX-2 in gastric carcinoma and its relationship. Methods: The expressions of NF-κB and COX-2 in 142 cases of gastric cancer were detected by immunohistochemical SP method. The corresponding normal tissues (30 cases) were used as controls. Results: The positive expression rate of NF-κB in gastric cancer was 62.0%, which was significantly higher than that in the control group (P <0.01). The expression of NF-κB was significantly correlated with histological type, lymph node metastasis and distant metastasis (P <0.05). The positive rate of COX-2 in gastric cancer tissues was 64.1%, but there was no significant difference between the two groups (P <0.01). The positive rate of COX-2 in lymph node metastasis group was significantly higher than that in non-metastasis group (P < 0.01). There was a significant positive correlation between NF-κB and COX-2 expression in gastric cancer (r = 0.380, P <0.01). Conclusion: NF-κB and COX-2 play an important role in the carcinogenesis and progression of gastric cancer. NF-κB may promote the expression of COX-2.