目的探讨二甲基乙酰胺职业接触时间的不同对肝损害的程度是否存在差异。方法现场检测确定二甲基乙酰胺浓度,根据职业接触人群在职期间的健康监护数据,用SPSS 20.0软件包,分别计算参检者的肝脏指数,并采用卡方检验和方差分析(ANOVA)进行统计学分析。结果二甲基乙酰胺职业接触会引起肝脏损害。不同性别接害员工肝功能异常率差异有统计学意义(χ2=12.588,P<0.01);不同接害年限工人的肝脏损伤程度存在差异,且差异有统计学意义(F=12.043,P<0.01)。结论二甲基乙酰胺对职业接触人群的肝损害程度在不同接害时间下存在差异,随着接害时长的累积或可产生耐受效应。 Objective To investigate whether there is difference in the degree of liver damage caused by different occupational exposure times of dimethylacetamide. Methods The concentration of dimethylacetamide was determined on-site. According to the health monitoring data of occupational occupational occupational groups, the liver index of the participants was calculated by SPSS 20.0 software package and the data were analyzed by chi-square test and analysis of variance (ANOVA) Analysis. Results Dimethylacetamide causes liver damage due to occupational exposure. There were significant differences in the abnormal liver function rate between employees with different sexes (χ2 = 12.588, P <0.01). There was significant difference in the degree of liver injury among workers with different exposure years (F = 12.043, P <0.01) ). Conclusion The degree of hepatic damage caused by dimethylacetamide in occupationally exposed people is different under different exposure time, and the tolerance effect may be produced with the accumulation of injury duration.