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为研究１，３二甲基－６［２－（Ｎ－２羟乙基－３－４硝苯丙氨基）乙氨基］－２，４（１Ｈ，３Ｈ）－盐酸嘧啶二酮即ＭＳ－５５１（简称ＭＳ）对麻醉犬心肌的电生理作用和血液动力学影响，采用自身前后对照的方法测定用药（５ｍｉｎ内每公斤体重静脉注射ＭＳ０．５ｍｇ，继以每公斤体重静脉滴注０．５ｍｇ持续３０ｍｉｎ）前后麻醉犬（ｎ＝８）有关电生理参数及心输出量、肺毛细血管楔嵌压等变化。结果表明ＭＳ：①使心房有效不应期和心室有效不应期显著延长，分别为２７．１±６．８，２０．７±５．２ｍｓ，Ｐ均＜０．０１。②使自发性窦性周期、窦房结恢复时间和校正的窦房结恢复时间均显著延长，分别为４１．４±８．０，５０．０±９．８，８．６±３．４ｍｓ，前两者Ｐ＜０．０１，后者Ｐ＜０．０５。但对窦房传导时间无明显影响（３．６±１．８ｍｓ，Ｐ＞０．０５）。③对ＡＨ、ＨＶ、ＰＱ间期及ＱＲＳ波群时限无明显影响，显著延长ＱＴ间期，明显降低文氏点（调搏周长延长）。④轻度减低心输出量，但无统计学意义（变化值：－０．５６±０．２３Ｌ／ｍｉｎ，Ｐ＝０．０６１），对肺毛细血管楔嵌压无显著性影响。结论：ＭＳ延长心肌不应期，对心内传导影响不明显，有良好的血液动力学特性，可?
To investigate the effect of 1,3-dimethyl-6 [2- (N-2hydroxyethyl-3-4nitrophenylamino) ethylamino] -2,4 (1H, 3H) -pyrimidinedione hydrochloride, MS-551 (MS) anesthetized dogs myocardial electrophysiological effects and hemodynamic effects using its own control method before and after the test (5min per kg body weight intravenous injection of MS0.5mg, followed by intravenous infusion of 0.5mg per kg body weight continued 30min) anesthesia dogs (n = 8) on the electrophysiological parameters and cardiac output, pulmonary capillary wedge pressure and other changes. The results showed that MS: ① the effective refractory atrial and ventricular effective refractory period was significantly prolonged, respectively 27.1 ± 6.8,20.7 ± 5.2ms, P <0.01. ② spontaneous sinus cycle, sinus node recovery time and corrected sinus node recovery time were significantly longer, respectively, 41.4 ± 8.0,50.0 ± 9.8,8.6 ± 3.4ms , The former two P <0.01, the latter P <0.05. But no significant effect on the sinoatrial conduction time (3.6 ± 1.8ms, P> 0.05). ③ There was no significant effect on the duration of AH, HV, PQ and QRS complex, significantly prolonging the QT interval and significantly reducing Wen’s point (prolongation of pacing circumference). ④ mild decrease in cardiac output, but not statistically significant (change: -0.56 ± 0.23L / min, P = 0.061), the wedge pressure on the pulmonary capillary no significant effect. Conclusion: MS prolonged myocardial refractory period, the impact on cardiac conduction is not obvious, have good hemodynamic properties, can?