佛罗里达州肾脏学中心主任Bourgoignie教授,曾观察到慢性血液透析病人普遍有甲状旁腺功能亢进,其原因可能是钙吸收不良和维生素D缺乏。在透析液内增加钙的浓度,以及采取抑制肠道吸收磷酸盐的措施,都可减轻甲状旁腺功能亢进。但以前所有透析8年以上的病人都已切除了甲状旁腺。他最近发现口服甲氰咪胍(cimetidine)能有效地控制血循环中的甲状旁腺激素,这是一种“化学性甲状旁腺切除术”。 Professor Bourgoignie, director of the Florida Nephrology Center, has observed that hyperparathyroidism is common in chronic hemodialysis patients because of poor calcium absorption and vitamin D deficiency. Increase in the dialysate calcium concentration, and to take measures to inhibit the intestinal absorption of phosphate, can reduce hyperparathyroidism. However, all previous patients who had been on dialysis for more than 8 years had their parathyroid glands removed. He recently found that oral cimetidine effectively controls parathyroid hormone in the blood circulation, a “chemical parathyroidectomy.”