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目的观察盐酸纳美芬联合脑苷肌肽治疗重度颅脑损伤的疗效。方法将52例重度颅脑损伤患者随机分为治疗组和对照组，每组26例，观察两组患者的格拉斯哥GCS 评分治疗结果分级(GOS)。结果两组GCS 评分和GOS的有效率、死亡率差异具有显著性(P<0.05)。结论盐酸纳美芬联合脑苷肌肽治疗重度脑挫伤效果较好，值得临床推广。“,”Objective:To explore the observation of curative ef ect of nalmefene and cerebroside carnosine on severe cerebral injury . Methods:56 patients with severe cerebral injury were randomly divided into treatment group (26cases) with nalmefene and cerebroside carnosine and normal group (26cases) . The GCS and GOS clinical data after treatment were observed. Results The GCS and GOS significantly dif erence in the treatment group compared to the control group (P<0.05). Conclusion Nalmefene and Cerebroside carnosine is ef ective for severe cerebral injury,thus it is worthy of recommendation in clinical.