患儿,男,3天。系第一胎第一产,足月顺产,出生体重3.25kg。因生后24h出现黄疽,进行性加重且伴阵发性双目凝视2天入院。母妊娠期无疾病及药物史,无输血、流产及接受血制品疗法史。查体:体温36℃,脉搏120/min,呼吸22/min,急性重病容,呼吸浅慢,对外界刺激反应差,不哭,阵发性双目凝视呈惊恐状。全身皮肤粘膜重度黄染,前囟2cm×2cm,平坦。心肺正常,腹平坦,肝脾肋下未及, Children, male, 3 days. Department of the first birth of the first birth, term full-term, birth weight 3.25kg. Because of jaundice after birth, progressive increase with paroxysmal binocular staring 2 days admission. No pregnancy and drug history of pregnancy, no blood transfusion, abortion and receiving blood products therapy history. Physical examination: body temperature 36 ℃, pulse 120 / min, breathing 22 / min, acute serious illness, slow breathing, poor response to external stimuli, do not cry, paroxysmal binocular staring was panic. Severe yellowish skin and mucous membrane, bregma 2cm × 2cm, flat. Cardiopulmonary normal, flat belly, liver and spleen ribs,