过敏毒素C3a和C5a是体内补体激活过程中由c3和C5裂解出来的活性片段,具有较强的炎症、免疫调节和免疫学特性。C3a和C5a分别为9000和11000道尔顿的小肽,pH稳定范围在1—10之间,耐受100℃15分钟。具有收缩平滑肌,刺激肥大细胞释放组织胺,增加血管壁通透性,使白细胞粘附、聚集,趋化并释放氧自由基、弹性蛋白酶、溶酶体 Anaphylatoxins C3a and C5a are active fragments cleaved by c3 and C5 during in vivo complement activation and have strong inflammatory, immunomodulatory and immunological properties. C3a and C5a were small peptides of 9000 and 11000 daltons, respectively, with a pH stability range of 1-10 and a toleration of 100 ° C for 15 minutes. Smooth muscle contraction, stimulation of mast cells release histamine, increased vascular wall permeability, leukocyte adhesion, aggregation, chemotaxis and release of oxygen free radicals, elastase, lysosome