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目的:评价改良FOLFOX方案一线治疗老年晚期胃癌的近期疗效和不良反应。方法:40例老年晚期胃癌,给予改良FOLFOX方案治疗。按RECIST标准评价近期疗效,WHO标准评价不良反应。结果:获得完全缓解4例,部分缓解20例,稳定10例,进展6例,总有效率(完全缓解+部分缓解)为60.0%。主要不良反应为恶心、呕吐、骨髓抑制及一过性神经感觉异常,全组无治疗相关性死亡。结论:改良FOLFOX方案治疗老年晚期胃癌患者有效,临床缓解率较高,不良反应轻,患者可以耐受。
Objective: To evaluate the short-term efficacy and side effects of modified FOLFOX regimen in the treatment of elderly patients with advanced gastric cancer. Methods: Forty elderly patients with advanced gastric cancer were treated with modified FOLFOX regimen. According to RECIST standard evaluation of recent efficacy, WHO standard evaluation of adverse reactions. Results: Four cases were achieved complete remission, partial remission in 20 cases, stable in 10 cases and progression in 6 cases. The total effective rate (complete remission + partial remission) was 60.0%. The main adverse reactions were nausea, vomiting, myelosuppression and transient neurosensory abnormalities. There was no treatment-related death in the whole group. Conclusion: The modified FOLFOX regimen is effective in elderly patients with advanced gastric cancer. The clinical remission rate is high, the adverse reactions are mild and the patients can tolerate.