肿瘤是一类常见病、多发病,其中恶性肿瘤是目前危害人类健康最严重的疾病之一,在我国,随着人口老龄化,肿瘤发病率和死亡率都呈增长趋势。近年来细胞外基质蛋白periostin备受关注,多项研究表明其与肿瘤发生存在密切关系。迄今为止,已发现periostin在众多组织和病理状态下均表达,包括骨,皮肤,牙周膜韧带,受损肌肉及血管,梗塞心肌,卵巢上皮细胞癌,结直肠癌,以及 Tumor is a common disease and frequently-occurring disease. Malignant tumor is one of the most serious diseases that endanger human health. In our country, as the population ages, the incidence of cancer and mortality are on the rise. In recent years, the extracellular matrix protein periostin has drawn much attention and many researches show that it is closely related to tumorigenesis. To date, periostin has been found to be expressed in a wide range of tissues and pathologies including bone, skin, periodontal ligament, damaged muscle and blood vessels, infarcted myocardium, epithelial ovarian cancer, colorectal cancer, and