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目的:观察七叶皂苷钠对老年结直肠癌患者术后肠道功能的影响。方法:将老年结直肠癌41例,随机分为七叶皂苷钠治疗组(观察组)22例和对照组19例。观察组采用七叶皂苷钠20 mg/d静脉滴注,1次/d,连续7天;对照组采用5%葡萄糖液作为安慰剂静脉滴注,给药时间和次数同观察组。比较两组术后首次肠鸣音恢复时间、首次排气和首次排便时间,恶心、腹胀、腹痛、吻合口漏等不良反应发生情况,以及术后住院时间等。结果:观察组术后首次肠鸣音恢复时间,首次排气、首次排便时间,以及术后住院时间均非常显著早于或短于对照组(P<0.01);两组体温、脉搏、呼吸频率、血压、手术时间、术中出血量、不良反应发生情况差异均不显著(P>0.05)。结论:七叶皂苷钠可促进老年结直肠癌患者术后肠道功能的恢复,缩短其住院时间。
Objective: To observe the effect of sodium aescinate on postoperative intestinal function in elderly patients with colorectal cancer. Methods: 41 elderly patients with colorectal cancer were randomly divided into sodium aescinate treatment group (observation group) 22 cases and control group 19 cases. The observation group was treated with sodium aescinate 20 mg / d intravenously once a day for 7 days. The control group received 5% dextrose solution as placebo for intravenous infusion. The time and number of administration were the same as those of the observation group. The first postoperative bowel sounds recovery time, first time of defecation and defecation time, nausea, bloating, abdominal pain, anastomotic leakage and other adverse reactions were compared between the two groups, as well as postoperative hospital stay. Results: The first bowel sound recovery time, the first discharge, the first defecation time and the postoperative hospital stay in the observation group were significantly earlier or shorter than those in the control group (P <0.01). The body temperature, pulse rate, respiratory rate Blood pressure, operation time, intraoperative blood loss, adverse reactions were not significantly different (P> 0.05). Conclusion: Sodium aescinate can promote the recovery of intestinal function in elderly patients with colorectal cancer and shorten the hospital stay.