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某些没有离子性基团或碱性很弱的药物,如要求经静脉大剂量注射并要求药物浓度超过其固有的溶解度,而采用控制赋形剂pH的方法并不能增加药物的溶解度时,药剂工作者使用了含有非水助溶剂的赋形剂。本文介绍利用助溶剂[丙二醇(PG)-盐水]配制一种在临用前稀释的高浓度注射剂的方法。引用了一个具体实例。一个碱性很弱的半极性化合物(4℃时溶解度为3mg/
Some drugs that do not have ionic groups or are weakly basic require that intravenous bolus injection require that the drug concentration exceed its intrinsic solubility and that using a method that controls the excipient pH does not increase the solubility of the drug Workers used excipients that contained non-aqueous cosolvents. This article describes a method of using a cosolvent [propylene glycol (PG) - saline] to prepare a high-concentration injection for dilution just prior to use. Cite a concrete example. A very weakly alkaline semipolar compound (4 ° C solubility 3mg /