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在２３例体外培养的人垂体ＧＨ分泌瘤细胞观察Ｃａ~（２＋）通道阻断剂尼卡地平和尼非地平、Ｃａ~（２＋）载体Ａ２３１８７对ＧＨ分泌瘤细胞ＧＨ基础分泌和ＧＲＨ／ＳＲＩＦ类似物ＳＭＳ刺激／抑制ＧＨ分泌的影响，同时观察ＧＲＨ和ＳＭＳ对~（４５）Ｃａ内流的作用。发现大多数ＧＨ瘤的ＧＨ分泌依赖Ｃａ~（２＋），但由Ｃａ~（２＋）介导的ＧＨ分泌过程有不同环节的异常，在ＧＲＨ和ＳＲＩＦ调节Ｃａ~（２＋）系统中分别有６６．７％（６／９例）和５５．６％（５／９例）的瘤细胞培养存在受体及受体后Ｃａ~（２＋）通道和Ｃａ~（２＋）－ＧＨ分泌偶联异常，这些异常可能与ＧＨ瘤的高分泌有关。
The GH basal secretion of GH secreting tumor cells and GRH/SRIF were similarly observed in 23 human pituitary GH-secreting tumor cells cultured in vitro and Ca~(2+) channel blockers nicardipine and nifidipine, Ca~(2+) vector A23187. The SMS stimulated/inhibited the effects of GH secretion while observing the effects of GRH and SMS on ~(45)Ca influx. The GH secretion of most GH tumors was found to be dependent on Ca 2+ , but the GH secretion process mediated by Ca 2+ had abnormalities at different stages. There were 66% of GR 2+ and SRIF-regulated Ca 2+ systems, respectively. In 7% (6/9 cases) and 55.6% (5/9 cases) of tumor cell cultures, abnormal coupling of Ca~(2+) channels and Ca~(2+)-GH secretion was observed in the presence of receptors and receptors. Abnormalities may be related to the high secretion of GH tumors.