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目的：观察急性心肌梗塞（ａｃｕｔｅｍｙｏｃａｒｄｉａｌｉｎｆａｒｃｔｉｏｎ，ＡＭＩ）患者血浆内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）与肾素活性（ｒｅｎｉｎａｃｔｉｖｉｔｙ，ＲＡ）、血管紧张素Ⅱ（ａｎｇｉｏｔｅｎｓｉｎⅡ，ＡＴ－Ⅱ）的变化及葛根素对其影响。方法：将４３例ＡＭＩ患者分为两组，分别接受葛根素（２３例）及极化液（２０例）治疗，以放免法检测治疗前及治疗后不同时期血浆ＥＴ、ＲＡ及ＡＴ－Ⅱ活性的变化。结果：ＡＭＩ患者血浆ＥＴ、ＲＡ及ＡＴ－Ⅱ血活性明显高于健康对照组（Ｐ＜０．０１），且ＥＴ与ＲＡ及ＡＴ－Ⅱ间均存在着显著正相关（Ｐ＜０．０１）；经葛根素治疗后血浆ＥＴ及ＲＡ、ＡＴ－Ⅱ在３天内恢复至正常，而经极化液治疗组血浆ＲＡ及ＡＴ－Ⅱ于７天方恢复接近正常，ＥＴ在１４天才降至正常。结论：葛根素是对ＡＭＩ患者异常反应的神经内分泌系统有重要调节作用的药物。
Objective: To observe the changes of plasma endothelin (ET), renin activity (RA) and angiotensin Ⅱ (AT-Ⅱ) in patients with acute myocardial infarction (AMI) and the effect of puerarin. Methods: 43 patients with acute myocardial infarction (AMI) were divided into two groups and received puerarin (23 cases) and pooled solution (20 cases) respectively. The levels of ET, RA and AT-Ⅱ in plasma before and after treatment The change. Results: The plasma levels of ET, RA and AT-Ⅱ in AMI patients were significantly higher than those in healthy controls (P <0.01), and there was a significant positive correlation between ET and RA and AT-Ⅱ (P <0.01) The levels of plasma ET, RA and AT-Ⅱ returned to normal within 3 days after treatment with puerarin, while the levels of RA and AT-Ⅱ in the plasma of the two groups returned to normal after 7 days and the ET decreased to normal after 14 days. CONCLUSION: Puerarin is an important regulator of neuroendocrine system in patients with abnormal AMI.