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氧异安定是一种具有抗惊厥作用的苯二氮(艹卓)类药物,人体禁食时,本品口服吸收达90％。已知食物能影响某些药物的吸收速度和程度;有关食物对氧异安定生物利用度的影响已进行研究。 6名健康受试者全夜禁食,于次晨进标准餐后服药或在三餐分别进食后3小时服药(2×10mg/片)。采集血样并分析氧异安定的溶度。结果表明,食物除了能延缓药物吸收速率和降低血浆峰浓度外,其他无显著影响。作者认为:“每临床实践中食物对氧异安定的影响甚微。因此本品可在饭前、饭后或进餐时同服,对其到达稳态血浆浓度影响不大”。从理论上讲,本品与食物同服有一定意义,因为血浆浓度较低,其副作用如镇静等也可相应减轻。
Oxazepam is a benzodiazepine (anticonvulsant) class of drugs with anticonvulsant effect, oral absorption of up to 90% of the body when fasting. It is known that food can affect the rate and extent of absorption of certain drugs; the effect of food on the bioavailability of oxybenzamine has been studied. Six healthy subjects were fasted overnight and were admitted to standard diet on the following morning or taken 3 hours after their meals (2 × 10 mg / tablet) respectively. Blood samples were taken and analyzed for oxygen-dependent stability. The results showed that, in addition to food can delay the rate of drug absorption and reduce plasma peak concentration, the other no significant effect. The author believes that: “Every clinical practice, the effect of food on the oxygen of diazepam is very small, so this product can be before meals, after meals or with the same service, to reach its steady-state plasma concentration has little effect.” In theory, the goods and food with a certain sense, because of lower plasma concentrations, the side effects such as sedation can also be reduced accordingly.