论文部分内容阅读
目的 :预防和治疗抗甲状腺药物引起的白细胞减少和粒细胞缺乏。方法 :收集自 1995年～ 1998年住院和门诊确诊的 Graves病 471例 ,随机分为两组 ,一组 (A组 )口服抗甲状腺药物联合利血生及 Vitamin B4治疗。另一组 (B组 )单纯口服抗甲状腺药物。定期复查血常规和甲状腺功能。结果 :A组 (治疗组 )无 1例发生血细胞减少和粒细胞缺乏 ,B组 (对照组 )有 10 1例发生白细胞减少。结论 :口服抗甲状腺药物 (ATD)的严重副作用是白细胞减少和粒细胞缺乏 ,口服 ATD同时加服利血生和 Vitam in B4可防止由 ATD引起的白细胞减少和粒细胞缺乏。
Objective: To prevent and treat anti-thyroid drugs caused leukopenia and agranulocytosis. Methods: A total of 471 Graves patients diagnosed as inpatients and outpatients from 1995 to 1998 were randomly divided into two groups. One group (Group A) received oral antithyroid drugs combined with reserpine and Vitamin B4. The other group (group B) simply oral anti-thyroid drugs. Regular review of blood and thyroid function. Results: None of the A patients (treatment group) had cytopenia and agranulocytosis, and 101 patients in the B group (control group) had leukopenia. CONCLUSIONS: Serious side effects of oral anti-thyroid drugs (ATDs) are leucopenia and agranulocytosis. Oral ATD plus both kaempferol and Vitam in B4 prevent leukopenia and agranulocytosis caused by ATD.