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目的:通过研究P16蛋白表达与胃癌发生及胃癌临床病理因素的关系,以探讨检测P16蛋白在胃癌诊断及判断胃癌恶性程度、估计预后和指导临床治疗的临床病理学意义。方法:采用免疫组化S-P法,检测100例胃癌与20例正常胃黏膜组织中P16蛋白表达情况。结果:P16蛋白在胃癌中表达率(36.0%)明显低于正常胃黏膜组织(85.0%)(P<0.01);P16蛋白表达与肉眼类型、分化程度、浸润深度、淋巴结转移,TNM分期有关(P<0.05);P16蛋白表达与患者性别、年龄、原发灶部位无关(P>0.05)。结论:检测P16蛋白的表达对辅助胃癌的诊断有很高的价值,并可作为判断胃癌恶性程度、估计预后和指导临床治疗的临床病理参考指标。
OBJECTIVE: To investigate the relationship between the expression of P16 protein and the clinicopathological factors of gastric cancer, and to explore the clinicopathological significance of detecting the expression of P16 protein in gastric cancer and to determine the degree of malignancy, prognosis and clinical treatment. Methods: Immunohistochemical S-P method was used to detect the expression of P16 protein in 100 cases of gastric cancer and 20 cases of normal gastric mucosa. Results: The positive rate of P16 protein in gastric cancer was significantly lower than that in normal gastric mucosa (85.0%, P <0.01). The expression of P16 protein was correlated with the type of macroscopia, differentiation degree, depth of invasion, lymph node metastasis and TNM staging P <0.05). The expression of P16 protein was not related to the gender, age and the location of the primary tumor (P> 0.05). Conclusion: The detection of P16 protein expression is of great value in the diagnosis of gastric cancer, and can be used as a clinicopathological reference to judge the degree of malignancy, prognosis and clinical treatment.