急性骨髓性白血病有否染色体异常与临床表现密切相关,并可以此估计预后;染色体核型正常者比异常者生存期长。本病有半数在染色体C组、G组的特定部位出现异常。本文报告3例急性骨髓性白血病染色体C组、G组异常的观察,并结合若干文献予以讨论。例1 女,12岁。并发VonRecklinghausen’s病。疾病初发、缓解和再发期的染色体均显示45,XX-7异常核型,即所谓7单倍体。入院主诉:全身倦怠,面色不好。体检:中度贫血;全身有大小不等的瘀点和瘀斑,大的可达20cm;肝肋下5cm。末稍血Hb3.5g%,血小板4000/mm~3,白血球10,100/mm~3;涂片见幼稚细胞占75%,20μm大小,胞浆丰富,有嗜酸性微细颗 Acute myeloid leukemia has chromosomal abnormalities and clinical manifestations are closely related, and this prognosis can be estimated; normal karyotype than those with abnormal long survival. Half of the disease in the chromosome C group, G group of specific parts of the exception. This article reports 3 cases of acute myeloid leukemia chromosome C, G abnormal observation, and with some literature to be discussed. Example 1 Female, 12 years old. Concurrent Von Recklinghausen’s disease. Chromosomes in the initial, mitigating and relapse phases of the disease show aberrant karyotypes 45, XX-7, the so-called 7 haplotypes. Admitted to the hospital: systemic fatigue, looking bad. Physical examination: moderate anemia; body size ranging from petechia and ecchymosis, large up to 20cm; liver rib 5cm. End-stage blood Hb3.5g%, platelets 4000 / mm ~ 3, white blood cells 10,100 / mm ~ 3; smear see immature cells accounted for 75%, 20μm size, abundant cytoplasm, eosinophilic fine particles