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以聚丙烯酸树脂肠溶Ⅱ号为囊材，采用相分离－凝聚法制备了克拉霉素微球，该法微球得率为（９０．５±２．０）％（ｎ＝３），所得微球粒径为１５５．１±２６．３９μｍ（ｎ＝１０００），载药量为７５％，克拉霉素微球在蒸馏水中几乎不溶出，而在ｐＨ６．８磷酸盐缓冲溶...
The clarithromycin microspheres were prepared by the phase separation - coagulation method with polyacrylic acid enteric Ⅱ as the material. The yield of the microspheres was (90.5 ± 2.0)% (n = 3) Microsphere diameter of 155.1 ± 26.39μm (n = 1000), drug loading of 75%, clarithromycin microspheres in distilled water almost insoluble, and in pH6.8 phosphate buffer ...