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应用发色底物比色分析法,对42例正常人和52例急性白血病(AL)病人血浆组织纤溶酶原激活剂(t-PA)、组织纤溶酶原激活剂抑制剂(PAI)活性进行了检测.结果显示,初诊AL病人血浆t-PA活性较正常对照组显著升高(P<0.01),而PAI活性变化不显著;完全缓解期的AL病人,t-PA下降到正常范围;并发严重出血者,其t-PA活性和血小板计数与无出血者相比均有显著性差异(P<0.05);并发感染者,其PAI活性较非感染者及正常对照组均显著升高.提示血浆t-PA,PAI活性与AL病人不同的临床表现及其预后有关.
Using chromogenic substrate colorimetric assay, plasma t-PA, PAI (inhibitor of plasminogen activator) in 42 normal subjects and 52 acute leukemia (AL) The activity of t-PA in newly diagnosed AL patients was significantly higher than that of the normal control group (P <0.01), while the activity of PAI did not change significantly. In the patients with complete remission, t-PA decreased to the normal range (P0.05) .There was a significant difference in t-PA activity and platelet count between those with severe hemorrhage and those without hemorrhage (P0.05) .Patients with concurrent infection had significantly higher PAI activity than non-infected and normal controls Prompted plasma t-PA, PAI activity and AL patients with different clinical manifestations and prognosis.