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目的 中西医药辩证施治对 38例恶性脑瘤的临床疗效与传统的放化疗的疗效对照观察。方法 治疗组 38例用VM2 6 +MeCCNU化疗与中医药辨证配合 ;对照组 18例按常规仅作放疗或化疗。结果 治疗组总有效率 (CR +PR) 76 3% (2 9/38) ,胶质瘤与转移瘤有效率分别为91 6 % (2 2 /2 4)和 5 0 % (7/14)。对照组有效率 33 3% (6 /18)。主要毒副反应为食欲下降 ,恶心呕吐 ,骨髓抑制 ,多为Ⅱ～Ⅲ级。大部分病人通过中药调理 ,能达到“增效”和“减毒”之目的。结论 运用中医辨证论治配合化疗 ,治疗恶性脑瘤的综合有效率为 76 3% ,与传统单一放化疗的疗效 33 3%有显著的差异 (P <0 0 5 )
Objective To observe the curative effect of traditional Chinese and western medicine on 38 patients with malignant brain tumor and traditional radiotherapy and chemotherapy. Methods 38 cases of treatment group with VM2 6 + MeCCNU chemotherapy with traditional Chinese medicine syndrome differentiation; control group of 18 patients routinely for radiotherapy or chemotherapy. Results The total effective rate (CR + PR) was 76.3% (29/38) in the treatment group and 91.6% (22/24) and 50% (7/14) in the glioma and metastatic tumors, respectively . The control group was 33 3% (6/18). The main side effects of decreased appetite, nausea and vomiting, bone marrow suppression, mostly Ⅱ to Ⅲ grade. Most patients through traditional Chinese medicine conditioning, can achieve “synergistic” and “attenuated” purposes. Conclusions The total effective rate of treatment of malignant brain tumor with syndrome differentiation of traditional Chinese medicine and chemotherapy is 76.3%, which is significantly different from that of conventional single radiotherapy (33.3%) (P <0.05)