由于对丝虫抗原免疫应答的类型不同,宿主感染丝虫后的临床表现亦不同。在淋巴丝虫病中,微丝蚴血症病人通常无症状或对丝虫抗原应答低下;伴有淋巴水肿和象皮肿的淋巴炎症发作病人,通常无微丝蚴血症,且对丝虫抗原反应强烈。宿主对感染的不同应答,可能由于接触虫体抗原方式不同和虫体抗原形成中遗传决定性的差异造成。最引人注意的是患微丝蚴血症母亲的后代,出生前接触特异性抗原,能改变对寄生虫抗原的应答,然而尚不清楚这种改变的持续时间。 Due to the different types of immune response to filarial antigens, the clinical manifestations of the host after filarial infection are also different. In lymphatic filariasis, microfilaremia patients are usually asymptomatic or have a low response to filarial antigen; patients with lymphedema and lymphadenitis with elephantiasis usually have no microfilariae, Strong antigen reaction. Different responses of the host to the infection may be due to the genetic determinations of differences in the manner in which the antigen contacts the parasite and the formation of antigen in the parasite. Most notably, the offspring of mothers with microfilariae, who were exposed to specific antigens before birth, were able to alter their response to parasite antigens, although the duration of such changes was not yet known.