单纯饮食控制或加用磺脲类药物治疗不满意的Ⅱ型糖尿病人80例，分别给予阿卡波糖（48例）和二甲双胍（32例）治疗16周。结果二甲双胍降空腹血糖疗效高于阿卡波糖，总有效率分别为96.9％和85.7％，显效率为71．9％和47.6％。阿卡波糖降低餐后2h血糖的疗效高于二甲双胍，总有效率分别为97．6％，93．8％，显效率为71．4％，65．6％。两药均能明显降低糖化血红蛋白，且无显著差异。两药均不刺激胰岛素分泌，对肝、肾功能和血脂亦无影响。 Eighty patients with type 2 diabetes who were not satisfied with diet control or sulfonylurea treatment were treated with acarbose (48 cases) and metformin (32 cases) for 16 weeks. Results Metformin reduced fasting blood glucose more than acarbose, the total effective rate was 96.9% and 85.7%, respectively, and the effective rates were 71.9% and 47.6%. Acarbose to reduce blood sugar 2h postprandial effect than metformin, the total effective rate was 97.6%, 93.8%, markedly effective rate of 71.4%, 65.6%. Both drugs can significantly reduce glycosylated hemoglobin, and no significant difference. Two drugs do not stimulate insulin secretion, liver, kidney function and blood lipids also had no effect.