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本研究动态观察了扶正解毒汤及/或乙肝疫苗对慢性乙肝抗病毒效应的影响,并与常规护肝治疗组进行对照,以 HBV—M三系、PHSAR、HBV—DNA 及抗-HBcIgM 为观察指标。结果表明,扶正解毒汤配合乙肝疫苗治疗,对 HBV 复制指标 e 抗原近、远期阴转率为66.7%和69.2%,与对照组比较P<0.005;HBV—DNA 近、远期阴转率为45.5%和57.5%,与对照组比较 P<0.025。提示该疗法有显著抑制 HBV 复制的作用,并对其机理进行了初步探讨。
This study dynamically observed the effect of Fuzheng Jiedu Decoction and / or Hepatitis B vaccine on the antiviral effects of chronic hepatitis B, and compared with the conventional hepatoprotective therapy group, with HBV-M three lines, PHSAR, HBV-DNA and anti-HBcIgM as the observation index. The results showed that Fuzheng Jiedu Decoction combined with Hepatitis B vaccine treatment of HBV replication index e antigen near long-term negative conversion rate was 66.7% and 69.2%, compared with the control group P <0.005; HBV-DNA near and long-term negative conversion rate was 45.5% and 57.5%, respectively, compared with the control group P <0.025. It is suggested that this therapy has a significant inhibitory effect on HBV replication and its mechanism has been explored.