目前流感引起的死亡病例80％发生在65岁以上人群,而现有流感疫苗接种老年人的有效率仅为30％～50％。为提高疫苗的免疫原性,Chiron疫苗公司的研究人员开发出新型佐剂MF59。这是一种微流状、含胆固醇代谢产物角鲨烯的水包油乳剂,将聚山梨酸酯80和脱水山梨糖醇三油酸脂加入该乳剂中,经高压匀化,形成的角鲨烯颗粒大小为155nm。该佐剂可保存3年以上。 Currently, 80% of flu-induced deaths occur in people over the age of 65, compared with 30% to 50% of existing flu vaccinations in the elderly. To improve the immunogenicity of the vaccine, researchers at Chiron Vaccine developed the new adjuvant MF59. This is a microfluidic, cholesterol-containing oil squalene metabolite oil-in-water emulsion. Polysorbate 80 and sorbitan trioleate are added to the emulsion and homogenized by high pressure to form angle sharks The olefin particle size is 155 nm. The adjuvant can be stored for 3 years or more.